Metabolic glucose status and pituitary pathology portend therapeutic outcomes in acromegaly.

ABSTRACT:

Introduction

Acromegaly is frequently associated with impaired glucose tolerance and/or diabetes. To evaluate the relationship between glucose metabolism and acromegaly disease, we evaluated 269 consecutive patients from two referral centres.

Methods

Clinical presentation, pituitary tumor size and invasiveness, and pituitary pathology were captured in a dedicated database.

Results

131 women and 138 men with a mean age of 53.8 years were included. Of these, 201 (74.7%) presented with a macroadenoma and 18 (6.7%) with a microadenoma. Radiographic invasion was present in 91 cases (33.8%). Mean tumor diameter was 1.86 cm (0.2-4.6). Pituitary histopathologic findings revealed pure GH-producing somatotroph adenomas (SA) in 147 patients, prolactin-production by mixed lactotr

SUBMITTER: Cheng S 

PROVIDER: S-EPMC3767813 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature