Centrifugal expansion of fundus autofluorescence patterns in Stargardt disease over time.

ABSTRACT:

Objective

To study the longitudinal changes in autofluorescence in Stargardt disease to reveal aspects of disease progression not previously evident. Changes in autofluorescence reflect changing fluorophore compositions of lipofuscin and melanin in retinal pigment epithelial cells, which has been hypothesized to contribute to Stargardt disease pathogenesis.

Methods

We examined the temporospatial patterns of fundus autofluorescence with excitation at both 488 nm (standard fundus autofluorescence) and 795 nm (near-infrared autofluorescence) in a longitudinal case series involving 8 eyes of 4 patients (range of follow-up, 11-57 months; mean, 39 months). Image processing was performed to analyze spatial and temporal cross-modality associations.

Results

Longitudinal fundus

SUBMITTER: Cukras CA 

PROVIDER: S-EPMC3768260 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature