Nickel-catalyzed Suzuki-Miyaura couplings in green solvents.

ABSTRACT: The nickel-catalyzed Suzuki-Miyaura coupling of aryl halides and phenol-derived substrates with aryl boronic acids using green solvents, such as 2-Me-THF and tert-amyl alcohol, is reported. This methodology employs the commercially available and air-stable precatalyst, NiCl2(PCy3)2, and gives biaryl products in synthetically useful to excellent yields. Using this protocol, bis(heterocyclic) frameworks can be assembled efficiently.

SUBMITTER: Ramgren SD 

PROVIDER: S-EPMC3768281 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature