Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice.

ABSTRACT:

Background & aims

Nuclear factor-κB (NF-κB) is activated during early stages of pancreatitis. This transcription factor regulates genes that control many cell activities, including inflammation and survival. There is evidence that activation of NF-κB protects against pancreatitis, and, in other cases, that it promotes this disease. We compared the effects of NF-κB in different mouse models of pancreatitis to understand these complications.

Methods

To model constitutive activation of NF-κB, we expressed a transgene that encodes its p65 subunit or the inhibitor of κB kinase (IKK)2 in pancreatic acinar cells of mice. We analyzed effects on pancreatic tissues and levels of NF-κB target genes in these mice and compared them with mice that did not express transgenic p65 or IKK2 (c

SUBMITTER: Huang H 

PROVIDER: S-EPMC3769090 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature