Structures involved at the time of temporal lobe spikes revealed by interindividual group analysis of EEG/fMRI data.

ABSTRACT:

Purpose

We measured metabolic changes associated with temporal lobe (TL) spikes using combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). We selected 18 patients with temporal lobe epilepsy (TLE) who underwent a 2-h simultaneous EEG-fMRI and had unilateral or bilateral independent TL spikes for interindividual group analysis, in order to identify consistent blood oxygenation level dependent (BOLD) responses to TL spikes.

Methods

EEG was postprocessed and spikes were visually identified. fMRI data were preprocessed with motion correction, spatial smoothing, and removal of low frequency drifts. Spike timings were used as events for fMRI statistical analysis. Four hemodynamic response functions were used to account for variability in the BOLD

SUBMITTER: Kobayashi E 

PROVIDER: S-EPMC3769286 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature