Pleiotropy between genetic markers of obesity and risk of prostate cancer.

ABSTRACT:

Background

To address inconsistent findings of obesity and prostate cancer risk, we analyzed the association between prostate cancer and genetic markers of obesity and metabolism.

Methods

Analyses included 176,520 single-nucleotide polymorphisms (SNP) associated with 23 metabolic traits. We examined the association between SNPs and prostate cancer in 871 cases and 906 controls, including 427 high-grade cases with Gleason ≥ 7. Genetic risk scores (GRS) for body mass index (BMI) and waist-to-hip ratio (WHR) were also created by summing alleles associated with increasing BMI or WHR.

Results

Prostate cancer was associated with five loci, including cyclin M2, with P values less than 1 × 10(-4). In addition, the WHR GRS was associated with high-grade prostate cancer versus

SUBMITTER: Edwards TL 

PROVIDER: S-EPMC3769483 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature