Single nucleotide polymorphisms and risk of recurrence of renal-cell carcinoma: a cohort study.

ABSTRACT:

Background

Germline genetic polymorphisms might affect the risk of recurrence in patients with localised renal-cell carcinoma. We investigated the association between genetic polymorphisms and recurrence of renal-cell carcinoma.

Methods

We analysed germline DNA samples extracted from patients with localised renal-cell carcinoma treated at the Dana-Farber/Harvard Cancer Center (Boston, MA, USA). We selected a discovery cohort from a prospective database at the Dana-Farber/Harvard Cancer Center and selected a validation cohort from department records at the Brigham and Women's Hospital (Boston, MA, USA). We validated the findings from the discovery cohort in the validation cohort. We genotyped 70 genes involved in the pathogenesis of renal-cell carcinoma (including the VHL/HIF

SUBMITTER: Schutz FA 

PROVIDER: S-EPMC3769687 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature