Test for interactions between a genetic marker set and environment in generalized linear models.

ABSTRACT: We consider in this paper testing for interactions between a genetic marker set and an environmental variable. A common practice in studying gene-environment (GE) interactions is to analyze one single-nucleotide polymorphism (SNP) at a time. It is of significant interest to analyze SNPs in a biologically defined set simultaneously, e.g. gene or pathway. In this paper, we first show that if the main effects of multiple SNPs in a set are associated with a disease/trait, the classical single SNP-GE interaction analysis can be biased. We derive the asymptotic bias and study the conditions under which the classical single SNP-GE interaction analysis is unbiased. We further show that, the simple minimum p-value-based SNP-set GE analysis, can be biased and have an inflated Type 1 error rate. To o

SUBMITTER: Lin X 

PROVIDER: S-EPMC3769996 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature