Fatty acid remodeling in cellular glycerophospholipids following the activation of human T cells.

ABSTRACT: Changes in fatty acid (FA) and glycerophospholipid (GPL) metabolism associated with cell cycle entry are not fully understood. In this study FA-GPL remodeling was investigated in resting and proliferating primary human T cells. Significant changes were measured in the composition and distribution of FAs in GPLs following receptor activation of human T cells. The FA distribution of proliferating T cells was very similar to that of the human Jurkat T cell line and when the stimulus was removed from proliferating T cells, they stopped proliferating and the FA distribution largely reverted back to that of resting T cells. The cellular content of saturated and monounsaturated FAs was significantly increased in proliferating cells, which was associated with an induction of FA synthase and stearo

SUBMITTER: Robichaud PP 

PROVIDER: S-EPMC3770080 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature