Magnetic resonance frequency shifts during acute MS lesion formation.

ABSTRACT:

Objective

We investigated the evolution of new multiple sclerosis (MS) lesions over time using frequency shifts of the magnetic resonance (MR) signal.

Methods

Twenty patients with relapsing-remitting MS were serially scanned for 6 months at 1-month intervals. Maps of MR frequency shifts were acquired using susceptibility-weighted imaging. New lesions were identified by enhancement with gadolinium (Gd).

Results

Forty new lesions were identified as areas of signal increase on Gd-enhanced scans. Up to 3 months before lesion appearance, the frequency in areas of future Gd enhancement was not detectably different from the frequency in normal-appearing white matter. Rapid increase in MR frequency was observed between 1 month before and 1 month after Gd enhancement. Two mont

SUBMITTER: Wiggermann V 

PROVIDER: S-EPMC3770162 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature