Assay sensitivity and study features in neuropathic pain trials: an ACTTION meta-analysis.

ABSTRACT:

Objective

Our objective was to identify patient, study, and site factors associated with assay sensitivity in placebo-controlled neuropathic pain trials.

Methods

We examined the associations between study characteristics and standardized effect size (SES) in a database of 200 publicly available randomized clinical trials of pharmacologic treatments for neuropathic pain.

Results

There was considerable heterogeneity in the SESs among the examined trials. Univariate meta-regression analyses indicated that larger SESs were significantly associated with trials that had 1) greater minimum baseline pain inclusion criteria, 2) greater mean subject age, 3) a larger percentage of Caucasian subjects, and 4) a smaller total number of subjects. In a multiple meta-regression analys

SUBMITTER: Dworkin RH 

PROVIDER: S-EPMC3770199 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature