Prospective study of restless legs syndrome and mortality among men.

ABSTRACT:

Objective

To prospectively examine whether men with restless legs syndrome (RLS) had an increased risk of mortality.

Method

This was a prospective cohort study of 18,425 US men free of diabetes, arthritis, and renal failure in the Health Professionals Follow-up Study (HPFS). In 2002, RLS was assessed using a set of standardized questions. Deaths were identified from state vital statistics records, the National Death Index, family reports, and the postal system.

Results

During 8 years of follow-up (2002-2010), we documented 2,765 deaths. In an age-adjusted model, RLS was associated with a 39% increased risk of mortality (hazard ratio [HR] = 1.39; 95% confidence interval [CI] 1.19-1.62; p < 0.0001). The association between RLS and mortality was slightly attenuated after

SUBMITTER: Li Y 

PROVIDER: S-EPMC3770202 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature