Hippocampal interictal epileptiform activity disrupts cognition in humans.

ABSTRACT:

Objective

We investigated whether interictal epileptiform discharges (IED) in the human hippocampus are related to impairment of specific memory processes, and which characteristics of hippocampal IED are most associated with memory dysfunction.

Methods

Ten patients had depth electrodes implanted into their hippocampi for preoperative seizure localization. EEG was recorded during 2,070 total trials of a short-term memory task, with memory processing categorized into encoding, maintenance, and retrieval. The influence of hippocampal IED on these processes was analyzed and adjusted to account for individual differences between patients.

Results

Hippocampal IED occurring in the memory retrieval period decreased the likelihood of a correct response when they were contrala

SUBMITTER: Kleen JK 

PROVIDER: S-EPMC3770206 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature