Intravitreal chemotherapy for vitreous seeding in retinoblastoma: Recent advances and perspectives.

ABSTRACT: For decades intravitreal chemotherapy (IViC) remained virtually banished from the therapeutic armamentarium against retinoblastoma, except as a heroic attempt of salvage before enucleation in only eyes with refractory vitreous seeding. Very recently, we have initiated a reappraisal of this route of administration by (1) profiling eligibility criteria, (2) describing a safety-enhanced injection procedure, (3) adjusting the tumoricidal dose of melphalan, and (4) reporting an unprecedented efficacy in terms of tumor control of vitreous seeding. Since then, intravitreal chemotherapy is being progressively implemented worldwide with great success, but still awaits formal validation by the ongoing prospective phase II clinical trial. As far as preliminary results are concerned, IViC appears to a

SUBMITTER: Munier FL 

PROVIDER: S-EPMC3770220 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature