Hedgehog signaling in human medullary thyroid carcinoma: a novel signaling pathway.

ABSTRACT:

Background

Locally or widely metastatic medullary thyroid carcinoma (MTC) is difficult to treat, and therapeutic options are limited. Recently, kinase inhibitors have shown partial efficacy in this cancer, but there is a continued need for the development of novel therapeutics. Within this context, the Hedgehog (Hh) pathway has been implicated in several types of human tumors, and early clinical trials with Hh antagonists have validated Hh as a novel therapeutic target. For the first time, we evaluated Hh pathway activity in MTC, and examined the effect of Hh pathway perturbation in highly characterized MTC cell lines.

Methods

We examined immunohistochemical expression of the Hh signaling mediators Sonic Hedgehog (Shh) and Glioblastoma (Gli)2 in paraffin-embedded normal vers

SUBMITTER: Bohinc B 

PROVIDER: S-EPMC3770247 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature