Mesenchymal stem cells as an alternative for Schwann cells in rat spinal cord injury.

ABSTRACT:

Background

Spinal cord has a limited capacity to repair; therefore, medical interventions are necessary for treatment of injuries. Transplantation of Schwann cells has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity. Furthermore, accessible sources such as bone marrow stem cells have drawn attentions to themselves. Therefore, this study was designed to evaluate the effect of bone marrow-derived Schwann cell on functional recovery in adult rats after injury.

Methods

Mesenchymal stem cells were cultured from adult rats' bone marrow and induced into Schwann cells in vitro. Differentiation was confirmed by immunocytochemistry and RT-PCR. Next, Schwann cells were s

SUBMITTER: Zaminy A 

PROVIDER: S-EPMC3770252 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature