Modeling vascularized bone regeneration within a porous biodegradable CaP scaffold loaded with growth factors.

ABSTRACT: Osteogenetic microenvironment is a complex constitution in which extracellular matrix (ECM) molecules, stem cells and growth factors each interact to direct the coordinate regulation of bone tissue development. Importantly, angiogenesis improvement and revascularization are critical for osteogenesis during bone tissue regeneration processes. In this study, we developed a three-dimensional (3D) multi-scale system model to study cell response to growth factors released from a 3D biodegradable porous calcium phosphate (CaP) scaffold. Our model reconstructed the 3D bone regeneration system and examined the effects of pore size and porosity on bone formation and angiogenesis. The results suggested that scaffold porosity played a more dominant role in affecting bone formation and angiogenesis co

SUBMITTER: Sun X 

PROVIDER: S-EPMC3770300 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature