Neuroplasticity and functional recovery in multiple sclerosis.

ABSTRACT: The development of therapeutic strategies that promote functional recovery is a major goal of multiple sclerosis (MS) research. Neuroscientific and methodological advances have improved our understanding of the brain's recovery from damage, generating novel hypotheses about potential targets and modes of intervention, and laying the foundation for development of scientifically informed recovery-promoting strategies in interventional studies. This Review aims to encourage the transition from characterization of recovery mechanisms to development of strategies that promote recovery in MS. We discuss current evidence for functional reorganization that underlies recovery and its implications for development of new recovery-oriented strategies in MS. Promotion of functional recovery requires an

SUBMITTER: Tomassini V 

PROVIDER: S-EPMC3770511 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature