Association between obesity and vulnerability and serologic response to influenza vaccination in older adults.

ABSTRACT:

Background

Serologic response to influenza vaccination declines with age. Few other host factors are known to be associated with serologic response. Our objective was to determine whether obesity and vulnerability independently predicted serologic response to influenza vaccination.

Methods

Adults ≥ 50 years were recruited during the 2008-2009 influenza season. Subjects provided pre- and post-vaccination sera for measuring antibody titers to 2008-2009 vaccine components. Body mass index (BMI) was calculated as weight (kg)/height (m(2)). Data were collected on vulnerability using the vulnerable elders survey (VES13). Logistic regression evaluated the associations between obesity and vulnerability and the serologic response to vaccination (both seroprotection and seroconversion

SUBMITTER: Talbot HK 

PROVIDER: S-EPMC3770527 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature