Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.

ABSTRACT:

Background and purpose

Anti-inflammatory cytokine and its genetic variations may play an important role in the process of atherosclerosis. We assessed whether serum interleukin-10 (IL-10) and its genetic variations are associated with ischemic stroke in a Chinese general population.

Methods

An epidemiological survey on cardiovascular diseases and their risk factors was carried in a general population in Beijing in 2005. Serum IL-10, IL-6, p-selectin, soluble intercellular adhesion molecule-1 and C-reactive protein were analyzed using ELISA kits, while three IL-10 Single Nucleotide Polymorphisms (SNP) (rs1800872, rs1554286 and rs3021094) were genotyped in 1475 participants.

Results

A high serum IL-10 (top tertile) was significantly associated with ischemic stroke (mult

SUBMITTER: Xie G 

PROVIDER: S-EPMC3770660 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature