Local targeted therapy of liver metastasis from colon cancer by galactosylated liposome encapsulated with doxorubicin.

ABSTRACT: Since regional drug administration enables to maintain a high drug concentration within tumors, we compared the plasma concentration and biodistribution of doxorubicin (Dox) from drug-loaded conventional liposomes by local or systemic administration. The results demonstrated that drug concentration was substantially improved in liver as well as a decrease in blood and other organs by spleen injection mimicking portal vein perfusion (regional administration). To further investigate the targeted therapeutic effect of galactosylated liposome encapsulated doxorubicin (Dox) by regional administration, liver targeting liposomes were prepared by incorporating galactosylated-DPPE to conventional liposomes. Liposome uptake and targeting were verified in vitro and in vivo by fluorescence microscopy

SUBMITTER: Zhao C 

PROVIDER: S-EPMC3770687 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature