A systematic review and meta-analysis of changes in cognitive functioning in adults undergoing hematopoietic cell transplantation.

ABSTRACT: Evidence is mixed regarding the effects of hematopoietic cell transplantation (HCT) on changes in cognitive functioning among adults. Meta-analysis, which is designed to help reconcile conflicting findings, has not yet been conducted on studies of adults receiving HCT. To fill this gap, the current study provides a systematic review and meta-analysis of cognitive functioning in adults receiving HCT. A search of PubMed, PsycInfo, CINAHL, and Cochrane Library yielded 732 abstracts, which were independently evaluated by pairs of raters. Seventeen studies were systematically reviewed; 11 were retained for meta-analysis. There was agreement that cognitive impairments are evident for a subset of patients before HCT. Meta-analytical findings of 404 patients revealed no significant changes in cogn

SUBMITTER: Phillips KM 

PROVIDER: S-EPMC3770806 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature