Current understanding of conventional outflow dysfunction in glaucoma.

ABSTRACT:

Purpose of review

Regulation of intraocular pressure by the conventional (trabecular) outflow pathway is complicated, involving a myriad of mechanical and chemical signals. In most, intraocular pressure is maintained within a tight range over a lifetime. Unfortunately in some, dysfunction results in ocular hypertension and open-angle glaucoma. In the context of established knowledge, this review summarizes recent investigations of conventional outflow function, with the goal of identifying areas for future inquiry and therapeutic targeting.

Recent findings

Mechanical stimulation of conventional outflow cells due to intraocular pressure fluctuations impacts contractility, gene expression, pore formation, enzyme activity, and signaling. Numerous local signaling mediators in th

SUBMITTER: Stamer WD 

PROVIDER: S-EPMC3770936 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature