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Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

ABSTRACT: New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC3771327 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

Zhang Wei W   Fortman Jeffrey L JL   Carlson Jacob C JC   Yan Jinyong J   Liu Yi Y   Bai Fali F   Guan Wenna W   Jia Junyong J   Matainaho Teatulohi T   Sherman David H DH   Li Shengying S  

Chembiochem : a European journal of chemical biology 20130129 3

New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering. ...[more]

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