17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status.

ABSTRACT:

Background and purpose

Recently, a novel locus at 17q25 was associated with white matter hyperintensities (WMH) on MRI in stroke-free individuals. We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. If the association acts by promoting a small vessel arteriopathy, it might be expected to also associate with lacunar stroke.

Methods

We quantified WMH on MRI in the stroke-free hemisphere of 2588 ischemic stroke cases. Association between WMHV and 6 single-nucleotide polymorphisms at chromosome 17q25 was assessed by linear regression. These single-nucleotide polymorphisms were also investigated for association with lacunar stroke in 1854 cases and 51 939 stroke-free controls from METASTROKE. Meta-analyses with previous reports and a gen

SUBMITTER: Adib-Samii P 

PROVIDER: S-EPMC3771337 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature