The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model.

ABSTRACT:

Purpose

Laser-induced choroidal neovascularization (CNV) is a widely used model to mimic many features of CNV resulting from wet AMD. Macrophages have been implicated in the pathogenesis of AMD. Class A scavenger receptors, scavenger receptor-A (SR-A) and macrophage receptor with collagenous domain (MARCO), are expressed on macrophages and are associated with macrophage function. The goal of this study is to examine the role of macrophage scavenger receptors in immune cell recruitment and the formation of CNV.

Methods

Laser photocoagulation was performed in wild-type and knockout mice with deletion of SR-A (SR-A(-/-)), MARCO (MARCO(-/-)), or both SR-A and MARCO double knockout (DKO). Immune cell recruitment at different time points and CNV lesions at 14 days after laser trea

SUBMITTER: Jawad S 

PROVIDER: S-EPMC3771553 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature