Analyzing fixed points of intracellular regulation networks with interrelated feedback topology.

ABSTRACT:

Background

Modeling the dynamics of intracellular regulation networks by systems of ordinary differential equations has become a standard method in systems biology, and it has been shown that the behavior of these networks is often tightly connected to the network topology. We have recently introduced the circuit-breaking algorithm, a method that uses the network topology to construct a one-dimensional circuit-characteristic of the system. It was shown that this characteristic can be used for an efficient calculation of the system's fixed points.

Results

Here we extend previous work and show several connections between the circuit-characteristic and the stability of fixed points. In particular, we derive a sufficient condition on the characteristic for a fixed point to be un

SUBMITTER: Radde N 

PROVIDER: S-EPMC3771561 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature