Changes preceding interictal epileptic EEG abnormalities: comparison between EEG/fMRI and intracerebral EEG.

ABSTRACT:

Purpose

In simultaneous scalp electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), blood oxygen level dependent (BOLD) changes occurring before the spike have been sometimes described but could not be explained. To characterize the origin of this prespike BOLD signal change, we looked for electrographic changes in stereo-EEG (SEEG) possibly preceding the scalp spike in patients that showed early BOLD response in EEG/fMRI.

Methods

We studied four patients with drug-resistant focal epilepsy who underwent EEG/fMRI, showed a prespike BOLD response, and were then studied with depth electrodes for presurgical localization of the epileptic generator. Early BOLD responses in the region of the spike field were analyzed using models with hemodynamic response

SUBMITTER: Pittau F 

PROVIDER: S-EPMC3771927 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature