BMP7 expression correlates with secondary drug resistance in mantle cell lymphoma.

ABSTRACT:

Purpose

We designed a gene profiling experiment to identify genes involved in secondary drug resistance in mantle cell lymphomas (MCL).

Experimental design

We obtained paired tissue samples collected from the same patients before treatment and after relapse or progression. Variations in gene expression between the 2 samples were estimated for 5 patients. For each gene, the mean variation was estimated for patients with a refractory primary tumor and for responders who developed secondary drug resistance. Nine genes of interest were selected on the basis of the magnitude and statistical significance of the variation of expression in responders and non-responders.

Results

BMP7 was the only one with significantly increased expression at relapse in patients who developed

SUBMITTER: Camara-Clayette V 

PROVIDER: S-EPMC3771972 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature