Impact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery.

ABSTRACT:

Background

Although microRNA (miRNA) regulates initiation and/or progression of atrial fibrillation (AF) in canine AF models, the underlying mechanism in humans remains unclear. We speculated that certain miRNAs in atrial tissue are related to AF, and evaluated the relationship of miRNA expression in human atrial tissue in cardiac surgery patients.

Methods

Right atrial tissues from 29 patients undergoing cardiovascular surgery were divided into 3 groups [A: chronic AF or unsuccessful maze, n=6; B: successful maze, n=10; C: sinus rhythm (SR) n=13]. miRNA expression was determined using high density microarrays and with Reverse transcriptase-polymerase chain reaction (RT-PCR). Fibrosis was examined using Masson trichrome staining.

Results

miRNA microarray analysis showe

SUBMITTER: Nishi H 

PROVIDER: S-EPMC3772020 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature