Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction.

ABSTRACT:

Objective

The rs1333049, rs10757278 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus that are associated with prevalence of acute coronary syndromes (ACS). The rs1333049 SNP was also associated with cardiac outcome 6 months post ACS. No data concerning their association with long term prognosis after myocardial infarction is available. The aim of our study was to investigate the association of the 9p21.3 locus with 5-year overall mortality in patients with ST-elevation myocardial infarction (STEMI) treated invasively.

Materials and methods

We performed a retrospective analysis of data collected prospectively in a registry of consecutive patients with STEMI treated with primary PCI. Genotyping was performed with a TaqMan method. The analyzed e

SUBMITTER: Szpakowicz A 

PROVIDER: S-EPMC3772090 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature