Laboratory investigations on the diagnosis of tuberculosis in the malnourished tribal population of melghat, India.

ABSTRACT:

Background

Malnutrition is a major risk factor for the development of tuberculosis (TB). In India, Melghat is among the tribal regions which consist of highest number of malnutrition cases. Because of the paucity of TB data from these malnourished areas there is an urgent need for the development and evaluation of improved TB diagnostic tests. In the present study, three in house developed diagnostic tests namely TB-Ag(antigen) ELISA, Adenosine deaminase (ADA) estimation and IS6110 polymerase chain reaction (PCR) assay were investigated for the detection of Mycobacterium tuberculosis (M. tb.) infection.

Methods

For investigation, blood samples were collected from 128 study subjects from six villages of Melghat tribal area and evaluated using three in house developed assays,

SUBMITTER: Kashyap RS 

PROVIDER: S-EPMC3772098 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature