Different effects on bone strength and cell differentiation in pre pubertal caloric restriction versus hypothalamic suppression.

ABSTRACT: Hypothalamic amenorrhea and energy restriction during puberty affect peak bone mass accrual. One hypothesis suggests energy restriction alters hypothalamic function resulting in suppressed estradiol levels leading to bone loss. However, both positive and negative results have been reported regarding energy restriction and bone strength. Therefore, the purpose of this study was to investigate energy restriction and hypothalamic suppression during pubertal onset on bone mechanical strength and the osteogenic capacity of bone marrow-derived cells in two models: female rats treated with gonadotropin releasing hormone antagonists (GnRH-a) or 30% energy restriction. At 23 days of age, female Sprague Dawley rats were assigned to three groups: control group (C, n=10), GnRH-a group (n=10), and Ener

SUBMITTER: Joshi RN 

PROVIDER: S-EPMC3772180 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature