In silico approach for predicting toxicity of peptides and proteins.

ABSTRACT:

Background

Over the past few decades, scientific research has been focused on developing peptide/protein-based therapies to treat various diseases. With the several advantages over small molecules, including high specificity, high penetration, ease of manufacturing, peptides have emerged as promising therapeutic molecules against many diseases. However, one of the bottlenecks in peptide/protein-based therapy is their toxicity. Therefore, in the present study, we developed in silico models for predicting toxicity of peptides and proteins.

Description

We obtained toxic peptides having 35 or fewer residues from various databases for developing prediction models. Non-toxic or random peptides were obtained from SwissProt and TrEMBL. It was observed that certain residues like Cys,

SUBMITTER: Gupta S 

PROVIDER: S-EPMC3772798 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature