Differentiating primary progressive aphasias in a brief sample of connected speech.

ABSTRACT:

Objective

A brief speech expression protocol that can be administered and scored without special training would aid in the differential diagnosis of the 3 principal forms of primary progressive aphasia (PPA): nonfluent/agrammatic PPA, logopenic variant PPA, and semantic variant PPA.

Methods

We used a picture-description task to elicit a short speech sample, and we evaluated impairments in speech-sound production, speech rate, lexical retrieval, and grammaticality. We compared the results with those obtained by a longer, previously validated protocol and further validated performance with multimodal imaging to assess the neuroanatomical basis of the deficits.

Results

We found different patterns of impaired grammar in each PPA variant, and additional language production

SUBMITTER: Ash S 

PROVIDER: S-EPMC3772830 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature