Syndromes dominated by apraxia of speech show distinct characteristics from agrammatic PPA.

ABSTRACT:

Objective

We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS).

Methods

Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, age-matched controls = 30) who all had volumetric MRI, diffusion tensor imaging, F18-fluorodeoxyglucose and C11-labeled Pittsburgh compound B (PiB)-PET scanning, as well as neurologic and speech and language assessments, were included in this case-control study. AOS was classified as either type 1, predominated by sound distortions and distorted sound substitutions, or type 2, predominated by syllabically segmented prosodic speech patterns.

Results

The do

SUBMITTER: Josephs KA 

PROVIDER: S-EPMC3772832 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature