Multiparametric MRI study of ALS stratified for the C9orf72 genotype.

ABSTRACT:

Objective

To describe the patterns of cortical and subcortical changes in amyotrophic lateral sclerosis (ALS) stratified for the C9orf72 genotype.

Methods

A prospective, single-center, single-protocol, gray and white matter magnetic resonance case-control imaging study was undertaken with 30 C9orf72-negative patients with ALS, 9 patients with ALS carrying the C9orf72 hexanucleotide repeat expansion, and 44 healthy controls. Tract-based spatial statistics of multiple white matter diffusion parameters, cortical thickness measurements, and voxel-based morphometry analyses were carried out. All patients underwent comprehensive genetic and neuropsychological profiling.

Results

A congruent pattern of cortical and subcortical involvement was identified in those with the C9or

SUBMITTER: Bede P 

PROVIDER: S-EPMC3772833 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature