An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.

ABSTRACT:

Purpose

We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer.

Patients and methods

Using data on 3,349 cases and 3,654 controls from the PanScan Consortium, we developed a relative risk model for men and women of European ancestry based on non-genetic and genetic risk factors for pancreatic cancer. We estimated absolute risks based on these relative risks and population incidence rates.

Results

Our risk model included current smoking (multivariable adjusted odds ratio (OR) and 95% confidence interval: 2.20 [1.84-2.62]), heavy alcohol use (>3 drinks/day) (OR: 1.45 [1.19-1.76]), obesity (body mass index >30 kg/m(2)) (OR: 1.26 [1.09-1.45]), diabetes >3 years (nested case-control OR: 1.57 [1.13-2.18],

SUBMITTER: Klein AP 

PROVIDER: S-EPMC3772857 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature