Prognostic value of HIFs expression in head and neck cancer: a systematic review.

ABSTRACT:

Background

Tumor hypoxia plays a fundamental role in resistance to therapy and disease progression. A number of studies have assessed the prognostic role of HIFs expression in head and neck cancer (HNC), but no consistent outcomes are reported.

Methodology

A systematical search was performed to search relevant literatures in PubMed, Web of Science and ISI Web of Knowledge databases. The patients' clinical characteristics and survival outcome were extracted. The correlation between HIFs expression and prognosis was analyzed.

Principal findings

A total of 28 studies assessed the association between HIFs and HNC survival, the result showed that overexpressed HIFs was significantly associated with increase of mortality risk (HR = 2.12; 95% CI: 1.52-2.94; I(2) 74%). Subgro

SUBMITTER: Gong L 

PROVIDER: S-EPMC3772872 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature