Longitudinal trajectory of vitamin D status from birth to early childhood in the development of food sensitization.

ABSTRACT:

Background

Increasing evidence supports the immunomodulatory effect of vitamin D on allergic diseases. The combined role of prenatal and postnatal vitamin D status in the development of food sensitization (FS) and food allergy remains understudied.

Methods

Plasma 25-hydroxyvitamin D (25(OH)D) levels of 460 children in the Boston Birth Cohort (BBC) were measured at birth and early childhood, and the subjects were genotyped for rs2243250 (C-590T) in the IL4 gene. We defined FS as specific IgE levels of ≥0.35 kUA/l to any of eight common food allergens; we defined persistently low vitamin D status as cord blood 25(OH)D <11 ng/ml and postnatal 25(OH)D <30 ng/ml.

Results

We observed a moderate correlation between cord blood 25(OH)D at birth and venous blood 25(OH)D measure

SUBMITTER: Liu X 

PROVIDER: S-EPMC3773018 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature