PET reveals inflammation around calcified Taenia solium granulomas with perilesional edema.

ABSTRACT:

Objective

Neurocysticercosis, an infection with the larval form of the tapeworm, Taeniasolium, is the cause of 29% of epilepsy in endemic regions. Epilepsy in this population is mostly associated with calcified granulomas; at the time of seizure recurrence 50% of those with calcifications demonstrate transient surrounding perilesional edema. Whether edema is consequence of the seizure, or a result of host inflammation directed against parasite antigens or other processes is unknown. To investigate whether perilesional edema is due to inflammation, we imaged a marker of neuroinflammation, translocater protein (TSPO), using positron emission tomography (PET) and the selective ligand (11)C-PBR28.

Methods

In nine patients with perilesional edema, degenerating cyst or both, PET f

SUBMITTER: Fujita M 

PROVIDER: S-EPMC3773048 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature