The potential impact of adding genetic markers to clinical parameters in managing high-risk prostate cancer patients.

ABSTRACT:

Purpose

High-risk prostate cancer is a potentially lethal disease that is increasing in the diagnosis of prostate cancer patients. Compared to other prostate cancer patients (medium or low risk), management, diagnosis and treatment are not as successful among high-risk patients. Because the genetic characterization of prostate cancer patients is increasing, we aimed to determine whether genetic information in one of the primary associated genes, such as RNASEL (2', 5'-oligoadenylate-dependent RNase L), could be used as a biomarker to improve the quality of life and treatment among high-risk patients. The main objective is to identify genetic variants of RNASEL that could be associated with high-risk prostate cancer to improve the clinical managing of these patients.

Methods

SUBMITTER: Alvarez-Cubero MJ 

PROVIDER: S-EPMC3773101 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature