Ovarian function in Duarte galactosemia.

ABSTRACT:

Objective

To determine if girls with Duarte variant galactosemia (DG) have an increased risk of developing premature ovarian insufficiency based on prepubertal anti-Müllerian hormone (AMH) levels.

Design

Cross-sectional study.

Setting

University research laboratory.

Patient(s)

Study volunteers included 57 girls with DG, 89 girls with classic galactosemia (GG), and 64 control girls between the ages of <1 month and 10.5 years.

Intervention(s)

Blood sampling.

Main outcome measure(s)

We determined AMH and FSH levels in study volunteers with and without Duarte variant or GG.

Result(s)

FSH levels were significantly higher and AMH levels significantly lower in girls with GG than in age-stratified control girls, but there was no significant differe

SUBMITTER: Badik JR 

PROVIDER: S-EPMC3773175 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature