Genetic susceptibility for Alzheimer disease neuritic plaque pathology.

ABSTRACT:

Importance

While numerous genetic susceptibility loci have been identified for clinical Alzheimer disease (AD), it is important to establish whether these variants are risk factors for the underlying disease pathology, including neuritic plaques.

Objectives

To investigate whether AD susceptibility loci from genome-wide association studies affect neuritic plaque pathology and to additionally identify novel risk loci for this trait.

Design, setting, and participants

Candidate analysis of single-nucleotide polymorphisms and genome-wide association study in a joint clinicopathologic cohort, including 725 deceased subjects from the Religious Orders Study and the Rush Memory and Aging Project (2 prospective, community-based studies), followed by targeted validation in an in

SUBMITTER: Shulman JM 

PROVIDER: S-EPMC3773291 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature