Linking great apes genome evolution across time scales using polymorphism-aware phylogenetic models.

ABSTRACT: The genomes of related species contain valuable information on the history of the considered taxa. Great apes in particular exhibit variation of evolutionary patterns along their genomes. However, the great ape data also bring new challenges, such as the presence of incomplete lineage sorting and ancestral shared polymorphisms. Previous methods for genome-scale analysis are restricted to very few individuals or cannot disentangle the contribution of mutation rates and fixation biases. This represents a limitation both for the understanding of these forces as well as for the detection of regions affected by selection. Here, we present a new model designed to estimate mutation rates and fixation biases from genetic variation within and between species. We relax the assumption of instantaneou

SUBMITTER: De Maio N 

PROVIDER: S-EPMC3773373 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature