Costimulatory genes: hotspots of conflict between host defense and autoimmunity.

ABSTRACT: To understand the adaptations of costimulatory molecules through mammalian evolution, Forni et al. (Forni et al., 2013) studied evolutionary selection in key costimulatory genes. Their results, presented in this issue of Immunity, suggest that the risk of autoimmmunity is balanced against efficacy of the anti-pathogen immune response.

SUBMITTER: Jones JC 

PROVIDER: S-EPMC3773510 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature