Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia.

ABSTRACT: In addition to being causally linked to the formation of multiple tumor types, tobacco use has been associated with decreased efficacy of anticancer treatment and reduced survival time. A detailed understanding of the cellular mechanisms that are affected by tobacco smoke (TS) should facilitate the development of improved preventive and therapeutic strategies. We have investigated the effects of a TS extract on the transcriptome of MSK-Leuk1 cells, a cellular model of oral leukoplakia. Using Affymetrix HGU133 Plus 2 arrays, 411 differentially expressed probe sets were identified. The observed transcriptome changes were grouped according to functional information and translated into molecular interaction network maps and signaling pathways. Pathways related to cellular proliferation, inflam

SUBMITTER: Gumus ZH 

PROVIDER: S-EPMC3773527 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature