Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.

ABSTRACT:

Background

Vitamin D and its metabolites are believed to impede carcinogenesis by stimulating cell differentiation, inhibiting cell proliferation, and inducing apoptosis. Certain pesticides have been shown to deregulate vitamin D's anticarcinogenic properties. We hypothesize that certain pesticides may be linked to prostate cancer via an interaction with vitamin D genetic variants.

Methods

We evaluated interactions between 41 pesticides and 152 single-nucleotide polymorphisms (SNP) in nine vitamin D pathway genes among 776 prostate cancer cases and 1,444 male controls in a nested case-control study of Caucasian pesticide applicators within the Agricultural Health Study. We assessed Pinteraction values using likelihood ratio tests from unconditional logistic regression and a

SUBMITTER: Karami S 

PROVIDER: S-EPMC3773544 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature