Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle.

ABSTRACT: Nanoparticles are currently being investigated in a number of human clinical trials. As information on how nanoparticles function in humans is difficult to obtain, animal studies that can be correlative to human behavior are needed to provide guidance for human clinical trials. Here, we report correlative studies on animals and humans for CRLX101, a 20- to 30-nm-diameter, multifunctional, polymeric nanoparticle containing camptothecin (CPT). CRLX101 is currently in phase 2 clinical trials, and human data from several of the clinical investigations are compared with results from multispecies animal studies. The pharmacokinetics of polymer-conjugated CPT (indicative of the CRLX101 nanoparticles) in mice, rats, dogs, and humans reveal that the area under the curve scales linearly with milligr

SUBMITTER: Eliasof S 

PROVIDER: S-EPMC3773776 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature