Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors.

ABSTRACT: Proper functioning of sensory systems requires the generation of appropriate numbers and proportions of neuronal subtypes that encode distinct information. Perception of color relies on signals from multiple cone photoreceptor types. In cone-dominated retinas, each cone expresses a single opsin type with peak sensitivity to UV, long (L) (red), medium (M) (green), or short (S) (blue) wavelengths. The modes of cell division generating distinct cone types are unknown. We report here a mechanism whereby zebrafish cone photoreceptors of the same type are produced by symmetric division of dedicated precursors. Transgenic fish in which the thyroid hormone receptor β2 (trβ2) promoter drives fluorescent protein expression before L-cone precursors themselves are produced permitted tracking of their

SUBMITTER: Suzuki SC 

PROVIDER: S-EPMC3773785 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature